Latib, Marzida Abd
(2010)
Effects of garcjnia mangostana linn. on wound
healing in experimental wound models in rats:
a preliminary study.
Masters thesis, Universiti Sains Malaysia.
Abstract
Wound healing is a very complex interplay between the overlapping
phases, involving many cell types, mediators and growth factors. The an1ount of
knowledge and understanding concerning the wound healing process and dressing
practices has expanded and changed overtime. Its management is often costly.
Therefore researchers are exploring alternative solution from natural sources that
are useful in wound healing. Garcinia mangostana Linn. or mangosteen has never been scientifically studied
for its wound healing potential. However there are numerous in vivo and in vitro
studies that pointed to the medicinal properties of Garcinia mangostana L.
Therefore this study aims to explore and relate the medicinal properties to wound
healing in an animal wound model. The main objective of this study is to evaluate the effect of Garcinia mangostana
L. on specific wound healing properties in rats namely wound contraction, period
of epithelization and breaking strength. A semi quantitative histological
examination was also performed. The wound contraction and epithelization were
studied in an excision wound model which comprise of 10 rats in treatment group
and 10 rats which were not treated acted as control. The wound breaking strength
was studied in the incision wound model comprised of 6 rats in each group. This study demonstrated a significant increase in wound contraction at post
operative day one and post operative day five in wounds treated with Garcinia
mangostana L. extract with p value of< 0.001 and 0.005 respectively. It was also
found that the wound breaking strength was significantly higher in the treatment
group with p value of 0.04. Unfortunately semiquantitative histological analysis
did not show any significant difference in inflammation, angiogenesis and
fibroblast proliferation. In conclusion, Garcinia mangostana L. showed evidence of wound healing
promotion. However the exact mechanism is still vague requiring further in vitro
and in vivo studies before a clinical study could be performed.
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