Habibah, Abdul Hamid
(2010)
Prevalence of metabolic syndrome among postmenopausal
women and its associated factors at gynaecology clinic
HUSM.
Masters thesis, Universiti Sains Malaysia.
Abstract
The metabolic syndrome has been defined as a constellation of lipid and
non-lipid risk factors that increase subjects’ risk to develop cardiovascular disease
(CVD). The prevalence of the metabolic syndrome increases with age and after the
onset of menopause, and may explain in part the apparent acceleration of cardiovascular
disease in postmenopausal women determine the prevalence of metabolic syndrome among
postmenopausal women and its associated factors at Gynaecology clinic HUSM. A cross-sectional study of all postmenopausal women that was conducted in
Hospital Universiti Sains Malaysia. It involved all 411 patients who were postmenopausal and their age more than 45 years old, attending the Gynaecology clinic
HUSM. Sociodemographic data, waist circumference, weight, height and blood
pressure were recorded and a fasting blood sample obtained for serum glucose and
results. Metabolic syndrome was defined in accordance with criteria of International
Diabetic Federation (IDF).
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lipid profile determinations. Woman were counseled and managed according to the The mean age of participants Results: was 57.2 + 6.9 years. The prevalence of
metabolic syndrome, according to IDF criteria, was 36.7%. Using the same criteria,
100%, 78.8%, 67.5%, 58.3% and 53% of women presented with abdominal obesity
hypertension, low high density lipoprotein (HDL) cholesterol, hypertriglyceridemia and
diabetes, respectively. In this study we found that 92.2%, 71%, 42%, 19.4%, and 4.6%
of all the participants had at least one, two, three, four, or five components, respectively.
The risk of MS detection (univariate analysis) increased with presence of obstetric
history of HPT (odds ratio (OR) 2.64, 95% (CI) 1.25-5.62), family history of HPT (odds
ratio (OR) 1.71 , 95% (CI) 1.13-2.59) and obesity (odds ratio (OR) 2.59, 95% (CI)
1.08-6.23 ), and the usage of contraception (odds ratio (OR) 1.56, 95% (CI) 1.02-2.42).
However, only family history of Hypertension (HPT) which accounts 45.4% is the most
important associated risk factor to develop metabolic syndrome (MS) by using multiple
logistic regression analysis. There is a high prevalence of the metabolic syndrome in postmenopausal
Kelantan women seeking gynaecologic health care. The determinant factors of
metabolic syndrome related to previous obstetric HPT history, family history of HPT
and obesity, and contraception consumption. Therefore more effort should be
encouraged toward the implementation of lipid screening and educational programs
focused on high-risk populations to prevent cardiovascular morbidity and mortality
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