Adil S, Abd Alrazaq
(2011)
Study of concentration and morphology
of mechanoreceptors in the mucosa of
uncinate process of the human nose.
Masters thesis, Pusat Pengajian Sains Perubatan.
Abstract
To study the mechanoreceptors in the human nasal mucosa and to
compare the mean concentration of mechanoreceptors in the
Uncinate Process mucosa in patients with and without nasal
polyp. Subjects were 12 adult patients; six participants in the study group
(patient with nasal polyp) and six participants in control group
(patients without nasal polyp). Both groups underwent
functional endoscopic sinus surgery for their nasal pathology.
During operation 1 x 1 em from the uncinate process mucosa was
excised then fixed with formalin and sent to the pathology
laboratory for staining, each sample was stained for Calretininlabeled
antibody and Neurofilament- labeled antibody. After the
staining process, the slides were examined by light microscope. There were no cells identified to be stained by Calretinin antibody
in all 12 samples. However sample that stained with
Neurofilament antibody showed the presence of the nerve
terminals in the mucosa of all 12 samples. The mean
concentration of nerve terminals was significantly higher in
patients without nasal polyp (20.67±5.046) than for patients
with nasal polyp (11.67±7.257). The results suggest that there are no specific cells in the nasal
mucosa that act as mechanoreceptors. However the presence of
the nerve terminals in the nasal mucosa and between the
epithelial cells suggests that they are C-mechanoreceptors which
are thought to be polymodal nerve terminals. In addition,
reduction in the concentration of nerve terminals in patients with
nasal polyp can be the reason for the reduction or absence of the
feeling of nasal obstruction in some patients with nasal polyp.
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