Wan Soriany, Wan Md. Zain
(2013)
Effect of continuous and intermittent
exercise training programs on platelet
activation of healthy sedentary males.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
The purpose of this study is to investigate the effect of the continuous and intermittent training programs on platelet
activation. The hyper-activation of platelet may lead to the development of thrombotic event in cardiovascular disease
(CVD). Aerobic exercise is well known to reduce CVD risk and can reduce the platelet activation. There were 24 healthy
sedentary males mean aged 21.75±3.73 years old participated in this study and divided into 3 groups which are control
group (n=9), continuous group (n=7) and intermittent group (n=8). Platelet activation was measured via detection of the
P-selectin and glycoprotein llb-Jlla using jlowcytometry by indirect immunoflourescent. This study observed that, both
exercise groups pronounced the better changes. The intermittent type of training showed the decline of the gated
percentage of CD62p whereas the continuous group lowering the CD62p and PAC-I activation. As a conclusion, both
types of training programs provided the favorable effect on platelet activation. However, intermittent group pronounced
more beneficial effects on platelet activation whereas continuous group provide the beneficial changes on platelet
activation.
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