Wan Faiziah, Wan Abdul Rahman
(2013)
Expression of dna methylation of
homeodomain transcription factor 2 (pitx2)
and growth factor receptors in invasive
ductal carcinoma of the breast.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
A paired-like homeodomain transcription factor 2 (PITX2) is another new
marker in breast carcinoma when hypermethylation at P2 promoter of this gene was noted to
be associated with poor prognostic factor. We investigated the expression of PITX2 protein
using immunohistochemistry in invasive ductal carcinoma and its association with the
established growth receptors such as ER, PR and HER2.
We conducted a cross sectional study using 100 samples of archived formalin-fixed
paraffin embedded tissue blocks of invasive ductal carcinoma and stained them with
immunohistochemistry for PITX2, ER, PR and HER2. All HER2 with scoring of 2+ were confirmed
with CISH.
PITX2 protein was expressed in 53% of invasive ductal carcinoma and lack of PITX2
expression in 47%. Univariate analysis revealed a significant association between PITX2
expression with PR(p=0.001), ER(p=0.006), gland formation(p=0.044) and marginally associated
with molecular subtypes of breast carcinoma (p=0.051). Combined ER and PR expression with
PITX2 was also significantly associated (p=0.003) especially in double positive cases.
Multivariate analysis showed the most significant association between PITX2 and PR (RR 4.105,
95%CI1. 765-9.547, p=0.001).
PITX2 is another potential prognostic marker in breast carcinoma that able to
add significant information to established prognostic factors of ER and PR. The expression of
PITX2 together with PR may carry a very good prognosis.
Actions (login required)
 |
View Item |
