Zahali, Zunura'in
(2022)
Association between vitamin d and obesity related adipokines with breast cancer occurrence among women patients in Kelantan.
PhD thesis, Universiti Sains Malaysia.
Abstract
Breast cancer is a common carcinoma diagnosed among women worldwide as well as
Malaysia. Numerous studies reported the association between vitamin D and obesity
related adipokines with breast cancer development, yet the possible roles of these risk
factors remain scarce. Hence, the objective of this study was to determine the
association between serum vitamin D and obesity related adipokines (HMW
adiponectin and visfatin) with the development of breast cancer. This study was carried
out in Kelantan, Malaysia from July 2014 until June 2017. A case-control study was
conducted as a baseline recruitment and continued with follow-up of breast cancer
women at 18 months post-diagnosis. At baseline 78 newly-diagnosed breast cancer
patients and 85 healthy women aged 21 to 59 years old enrolled in this study. Data
collection consisted of socio-demographics, reproductives history, anthropometrics and
blood pressure measurement, as well as clinical biochemistry analysis. Multiple logistic
regression analysis showed that cotinine (OR = 1.22; 95% CI: 1.02, 1.48), waist
circumference (WC) (OR = 1.10; 95% CI: 1.02, 1.20), trigliseride (TG) (OR = 4.93;
95% CI: 1.83, 13.2) and fasting glucose (OR = 1.90; 95% CI: 1.25, 2.89) were
significantly associated with increased risk of breast cancer. Serum vitamin D (OR =
0.89; 95% CI: 0.83, 0.95) and high molecular weight (HMW) adiponectin (OR = 0.76,
95% CI: 0.59, 0.98) were significantly related with decreased risk of breast cancer
development. However, there was no significant association between Vitamin D
receptor (VDR) polymorphism (FokI, BsmI and TaqI) with breast cancer was observed.
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