Aida Hanum, Ghulam Rasool
(2013)
Obesity intervention outcome: i)the effect of
pharmacological intervention in failed
lifestyle intervention ii)weight loss
maintenance with cessation of
pharmacological intervention.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
This study aimed to determine the effect of anti-obesity drug treatment in
overweight and obese subjects who had failed to achieve satisfactory weight loss after a 9
months' weight loss intervention programme involving education on lifestyle modification. 25 subjects had originally undergone a 9 months' intervention programme
aimed to reduce weight involving education on lifestyle modification. 11 (8 females and 3 males)
subjects who had failed to reduce their weight satisfactorily (defined as still having body mass
index (BMI) 2: 27 kg/m2 after intervention) were offered anti-obesity drugs for a period of 4
months. Anthropometric measurements, body composition (body and visceral fat percentages),
metabolic and cardiovascular (CVS) profiles were measured at 9 months after completing
lifestyle modification, and repeated at the end of 4 months with anti-obesity drugs. Anti-obesity
drugs used in this study were orlistat 120 mg three times daily or sibutramine 10- 15 mg daily. subjects were on orlistat while 4 were on sibutrarnine. These 11 subjects did
not significantly reduce weight when they were on 9 months education on lifestyle modification,
mean weight before and after intervention was 75.7 (18.8) vs 76.5 (21.0) kg; p=0.452. Weight
reduced significantly after 4 months drug treatment by 2.06 kg (p=0.041). Visceral fat
significantly reduced from 13.7 (6.5)% to 12.9 (6.9)% (p=0.036) after drug treatment. A
borderline reduction in waist circumference was seen (87.2 (10.2) em vs 85.9 (11.0) em, (p =
0.073). No difference was seen in lipid profile, fasting blood sugar, insulin level and resistance,
blood pressure and arterial stiffuess with 4 months anti-obesity agents. Or!istat and Sibutramine reduced weight significantly in subjects who had
failed to reduce weight with education on lifestyle medication. The weight reduction was
however modest at 2.7% and was not associated with improvements in other CVS and metabolic
risk markers.
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