Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis

Candy, Chuah (2019) Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis. Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis.

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Abstract

Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G. intestinalis. Results showed that Giard1a treated with increased concentration of H20 2 demonstrated significant reduction in cell viability and significant increase reactive oxygen species production. We found that alpha-2 and alpha-3 giardin showed significant up-regulated transcriptional expression in H,O,-treated Giardia at 1 h time-point, whereas gene expression level of alpha-7.2 and alpha-7.3 giardin up-regulated significantly at 4h time-point Alpha-11 giardin demonstrated up-regulated gene expression at a later time-point (8h and 24h) in H,02- treated Giardia. Together these findings suggest that alpha giardins could serve as potential promising target for future drug design and vaccine development

Item Type: Article
Uncontrolled Keywords: Giardiasis
Subjects: R Medicine
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 22 Feb 2022 01:52
Last Modified: 22 Feb 2022 01:52
URI: http://eprints.usm.my/id/eprint/51603

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