Candy, Chuah
(2019)
Elucidating the roles of annexin-like molecules in
the protozoan parasite giardia intestinalis: an
approach to the control of giardiasis.
Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis.
Abstract
Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to
examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G.
intestinalis. Results showed that Giard1a treated with increased concentration of H20 2
demonstrated significant reduction in cell viability and significant increase reactive oxygen
species production. We found that alpha-2 and alpha-3 giardin showed significant up-regulated
transcriptional expression in H,O,-treated Giardia at 1 h time-point, whereas gene expression
level of alpha-7.2 and alpha-7.3 giardin up-regulated significantly at 4h time-point Alpha-11
giardin demonstrated up-regulated gene expression at a later time-point (8h and 24h) in H,02-
treated Giardia. Together these findings suggest that alpha giardins could serve as potential
promising target for future drug design and vaccine development
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