Isa, Khairul Anuar Md
(2008)
Prognostic factors on trabeculectomy among glaucoma patients in Kelantan.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: The study on trabeculectomy success rate in Malaysian population
was relatively scarce. Information on trabeculectomy success rate and prognostic
factors for trabeculectomy outcome is needed to help ophthalmologist to
determine the prognosis and search for better way to increase success rate of
trabeculectomy.
Objectives: To detennine the five year trabeculectomy success rate and to
identify the prognostic factors that may influence the trabeculectomy outcome
among glaucoma patients treated at HUSM.
Methodology: A retrospective record review study was conducted involving 96
glaucoma patients (96 eyes) who undetwent trabeculectomy from 1·S I January
1990 to 31st July 2006. Additional follow-up of one year after the recruitment of
the study subjects was done from 151 August 2006to31 si July 2007. All patients
who fulfilled the selection criteria were included in the study. The medical
records were reviewed by a single researcher with the help of senior consultant of
ophthalmology and important information on the variables of interest and
trabeculectomy outcome status were collected and recorded into a clinical form .
The Kaplan Meier and Cox Proportional Hazards regression analysis was used in
statistical analysis.
Results: The median trabeculectomy success time was 18.8 months and the
overall trabeculectomy success rate was 36. l % (95% CI: 25.6, 46.8) at five year.
Based on the Cox's regression analysis after adjusting other va1iables, the
significant prognostic factors that may influence trabeculectomy outcome was
history of previous ocular surgery (HR=2.31, 95% Cl: 1.21, 4.41; p=0.019).
Conclusion: Trabeculectomy success rate for glaucoma patients at HUSM was
acceptably low. The history of previous ocular surgery was identified as the only
significant prognostic factor for trabeculectomy failure.
Better post trabeculectomy management for glaucoma patient that had undergone
previous ocular surgery is recommended to obtain higher trabeculectomy success
rate in those patient.
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