Mustafa, Norlaili
(2008)
The efficacy of intravitreal triamcinolone versus aser photocoagulation in the primary treament of diabetic macular oedema.
Masters thesis, Universiti Sains Malaysia.
Abstract
Objective: To compare the efficacy and safety of intravitreal triamcinolone injection to
laser photocoagulation in the primary treatment of diabetic macular oedema.
Methodology: Forty patients with newly diagnosed diabetic macular oedema were
randomized into 2 groups 20 in 4mg intravitreal triamcinolone acetonide (IVT A) injection
of and 20 in laser photocoagulation group. Evaluation was done at three months and the
macular oedema was quantified using HRT II. Intraocular pressure elevation, lenticular
opacity and endophthalmitis were observed.
Results: Mean visual acuity for IVTA group was 0.935(0.223) at baseline and
0.405(0.223) at three months, p<0.01. Mean visual acuity for laser group was 0.795(0.315)
at baseline and 0.525(0.289) at three months, p<0.01. However, there was no statistically
significant difference between the two groups, p=0.151. Mean macular oedema index for
IVTA group was 2.539 (0.914) at baseline and 1.753 (0.577) at three months, p<0.01.
Mean macular oedema index for laser group was 2.139 (0.577) at baseline and
1.711(0.472) at three months, p<0.01. However, there was no statistically significant
difference between the two groups (p=0.811 ). The mean intraocular pressure was
statistically significant pre and post IVT A injection (p=0.032). There was no significant
cataract progression at three months in both groups, p=0.688 and no incidence of
endophthalmitis post IVT A injection at three months review.
Conclusion: Both IVT A and laser photocoagulation demonstrate good outcome as primary
treatment in diabetic macular oedema patients. The IVTA is a relatively safe procedure.
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