-, Sirajudeen
(2011)
The effects cross-fostering and melatonin
supplementation on the oxidant/antioxidant
status and development of hypertensioni In
spontaneously hypertensive rats.
The effects cross-fostering and melatonin supplementation on the oxidant/antioxidant status and development of hypertensioni In spontaneously hypertensive rats.
Abstract
This study examined the effects of either cross-fostering or melatonin supplementation alone or in
combination on the development of hypertension and renal antioxidanVoxidant system in SHR and WKY
rats. One-day-old offspring of SHR and WKY dams received melatonin ( 1 Omg/kg body weight) from
gestation day-1 cross-fostered to opposite strain of dam and these male offspring continued to receive
melatonin (10mg/kg body weight) up to 16 weeks of age. Systolic blood pressure (SSP) of male offspring
was recorded at the age of 4, 6, 8, 12 and 16 weeks, and the kidneys were collected for the estimation of
antioxidanVoxidant status at the end of each age category.
In cross-fostered SHR, SSP was significantly lower than that in SHR controls till the age of 12
weeks and TSARS was lower at 4 weeks. SSP in melatonin treated SHR offspring remained significantly
lower till the age of 16 weeks when compared to untreated SHR GPx and GST activities were
significantly higher at the age of 16 weeks, and total glutathione level was significantly higher at 4, 12 and
16 weeks in melatonin treated SHR when compared to untreated SHR In melatonin supplemented crossfostered
SHR, SSP was significantly lower at the age of 12 and 16 weeks when compared to untreated
cross-fostered SHR, but was significantly lower throughout the experimental period when compared to
untreated in-fostered SHR Activities of GPx and GST were higher in melatonin-treated cross-fostered
SHR aged 16 weeks, when compared to age-matched SHR and non-melatonin supplemented crossfostered
SHR
This study suggests that both melatonin supplementation and cross-fostering reduce the rate of
rise in SBP. A combination of melatonin supplementation and cross-fostering however did not confer any
additional impact on the blood pressure lowering effect of either melatonin or cross-fostering alone.
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