Nadia, Sedi
(2008)
Construction of dna vaccine expressing
serine repeat antigen (sera) malarial epitope
of
plasmodium falciparijm.
Other.
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia.
(Submitted)
Abstract
Malaria remains a serious public health problem and caused an estimated 2 million people
death worldwide annually. The current eontrol and treatment strategies are not effective in
eradicating malaria. 1n addition, the rising rates ot malaria drug resistant parasite in some
area worsen the situation especially against P. falciparum. Therefore, a more effective
vaeeine against malaria parasite is urgently needed. DNA vaeeination is a new approaeh to
control the malaria. Previous animai studies have shown that DNA vaccination was abie to
induce both humoral and cellular responses. In order to resolve this problem an asexual
blood stage antigen of P. falciparum, serine repeat antigen (SERA) is reported to be one of
the promising vaccine candidates. In this study A DNA vaccine expressing a synthetic 22
kDa protein (SE22) from the 47 kDa N-terminal domain of SERA was eonstrueted. The
p V AXi- SE22 construct was verified by PCR screening and sequencing. Hopefully thls
DNA vaccine will be further studied to reveal its potential in reducing malarial morbidity
and mortality.
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