Zarullail, Nor Hafizah
(2020)
Comparison between low and high pressure negative pressure wound therapy (NPWT) in diabetic foot wound in term of wound size reduction and wound bed preparation for secondary procedure.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: Healing of diabetic foot ulcer is often a challenging problem due to lack of
resistance against infection and presence of peripheral arterial disease in diabetic patients. The
use of negative pressure wound therapy (NPWT) to facilitate the healing of diabetic foot ulcer
had been studied by many people. To date, the optimal pressure for NPWT was -125mmHg.
The aim of this study is to compare the effectiveness of low pressure (-50 mmHg) and high
pressure (-100 mmHg) NPWT in term of wound size reduction and optimal wound bed
preparation for secondary procedure.
Methodology: This was a prospective interventional, randomized controlled trial study done
on patients with diabetic foot ulcer admitted to orthopaedic ward, Hospital Universiti Sains
Malaysia. A total of 58 patients which were randomly assigned into 2 groups either low
pressure (-50 mmHg) or high pressure (-100 mmHg) NPWT and the outcome measured were
wound size reduction and wound bed score. Patients demographic data were collected and
statistical analysis was done using repeated measure analysis of variance (ANOVA) to
determine the relationship between the treatment and outcomes measured.
Result: Both treatment groups show significance changes in term of wound size reduction and
wound bed score. However there is no significance difference when comparing in between
both treatment group with measured outcomes.
Discussion/Conclusion: Negative pressure wound therapy facilitate the healing of diabetic
foot ulcer by reducing the wound size and expediates wound bed preparation for secondary
procedure even though there were no significance difference in between the level of negative
pressure used. The level of negative pressure used should be tailored to individual patient and
the aim of treatment.
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