Chong, Nicholas Franklin Tow Mun
(2020)
Keloid : multicentre study on the outcome of multimodality management.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: Keloids are benign hyperproliferative growths of dermal fibroblasts characterized by the excessive deposition of extracellular matrix components, especially collagen, fibronectin, elastin, proteoglycans, and growth factors such as TGF-β. They remain difficult to improve despite a plethora of advocated treatment strategies frequently observed in daily clinical routine. Hence, multimodality treatment is often recommended for optimum control of the disease. This study aims to assess the outcome of intralesional triamcinolone acetonide (TAC) injections with concurrent scar massage in management of keloid scarring in our setting, in order to optimise its management in the local population.
Methods:This is a prospective observational study conducted in the Reconstructive Sciences Unit, Hospital UniversitiSains Malaysia (Hospital USM) and the Department of Plastic & Reconstructive Surgery, Hospital Kuala Lumpur (HKL). This study involves the collection of POSAS scores from patients with keloid scars while they undergo treatment with intralesional TAC injections with concurrent scar massage.The POSAS scores is used to analyse the treatment outcome of keloid scars in the Malaysian population.
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