Lee Loong, Chuen
(2007)
Hypervariable segment-! (HVS-I) Sequence Analysis
Of Chinese Population of Peninsular Malaysia.
Other.
PPSP, Universiti Sains Malaysia.
(Submitted)
Abstract
Throughout Malaysia history, most of the Peninsular Malaysian Chinese are known to
be populated by those migrated from the China during the British colonial era (Barbie, 1992).
The present study was undertaken to obtain information about the distribution of the existing
HVS-1 sequence variations in the Chinese population of Peninsular Malaysia. A few studies
have used RFLP analysis to characterize the mtDNA of Malaysian Chinese (Ismail, 2006;
Mokhtaruddin, 2006; Ballinger et al., 1992). The primary purpose of this study is to provide
HVS-1 sequence data by sequencing the HVS-1 of the 40 Chinese individuals from different
parts of Peninsular Malaysia. The secondary purpose is classification of mtDNA haplogroup
based on the HVS-1 sequence variation by alignment of samples sequence and Cambridge
Reference Sequence (CRS) (Andrew et al., 1999).
The samples were predicted to belong to the superhaplogroup M and haplogroup B in
relatively high frequency as inferred from the study done by Ballinger et al., (1992). Analysis
of HVS-1 within the control region (CR) of the mitochondrial genome revealed the presence
of eight haplogroups: B, F, M, MC, MD, MG, N, and R. These haplogroups are the
characteristics of Southeast Asian populations (Ballinger et al., 1992) and also found in
significant proportion in Han Chinese of China (Y ao et al., 2002). Result shows that
superhaplogroup M (includes MC, MD, and MG) is the most common haplogroup in the
studied samples (55%), followed by haplogroup B (18%).
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