Asif, Saba
(2020)
Evaluation of salivary cortisol, RANKL and OPG levels in chronic periodontitis patients attending Hospital Universiti Sains Malaysia.
Masters thesis, Universiti Sains Malaysia.
Abstract
Chronic periodontitis is a low grade inflammatory infection of supporting
periodontal structure ocurring in the presence of pathogenic flora and plaque biofilm
interaction with immune system over a period of time. Multiple risk factors such as
smoking, alcohol intake, stress, obesity and metabolic syndrome, diabetes mellitus, other
systemic diseases or conditions have been identified as a potential risk factors for this
disease. The aim for this study is to assess and evaluate the association between levels of
salivary cortisol, RANKL and OPG protein biomarkers in chronic periodontitis (CP)
patients. In this cross sectional study, clinical periodontal parameters [periodontal pocket
depth (PPD), clinical attachment level (CAL), plaque score (PS) and gingival bleeding
index (GBI)] were performed and DASS-21 scores were assessed from the survey form.
Protein concentrations for salivary cortisol, RANKL and OPG were assessed in study
groups consisting of mild chronic periodontitis patients in group 2, moderate to severe
chronic periodontitis patients in group 3 and healthy subjects in group 1 at Periodontic
Clinics of School of Dental Sciences, Hospital Universiti Sains Malaysia. Mean levels
for salivary cortisol, RANKL and OPG protein were higher for group 3 (moderate to
severe chronic periodontitis) with 7.46 ng/ml, 0.23 ng/ml and 1.78 ng/ml. Higher
depression, anxiety and stress score were also noted for group 3 (moderate to severe
chronic periodontitis) from DASS-21 questionairre. DASS scores were significantly
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