Rehman, Sarmed Saif-Ur
(2020)
Evaluation of matrix metalloproteinases(MMP-8, -9) in pregnant women attending Hospital USM.
Masters thesis, Universiti Sains Malaysia.
Abstract
Pregnancy increases the propensity to periodontal inflammation, which includes
an enhanced gingival bleeding tendency without specific plaque association, periodontal
pocket depth (PPD) and clinical attachment loss (CAL). These pregnancy-related
periodontal changes, however, seem to be reversible after delivery. Matrix
metalloproteinases (MMPs) and their regulators are connected to periodontal
inflammation and destruction. However, the presence and role of the salivary MMPs in
pregnancy-related inflammatory destruction are not well known. This study was aimed to
evaluate salivary levels matrix metalloproteinase-8 (MMP-8), matrix metalloproteinase-9
(MMP-9) and periodontal status changes during pregnancy. Salivary samples were
collected from 30 pregnant women and 30 non-pregnant women. The periodontal
examinations included probing pocket depth (PPD), clinical attachment level (CAL),
plaque score (PS), and gingival bleeding index (GBI) measurements. MMP-8 and MMP-
9 levels were measured by ELISA and association of salivary MMP-8 and MMP-9 with
periodontal parameters of pregnant group was also evaluated. The results of this study
showed that the salivary concentrations of MMP-8 and MMP-9 were significantly lower
in pregnant women as compared to non-pregnant women. MMP-8 levels were 0.19 ng/ml
and MMP-9 levels were 1.57 ng/ml in pregnant women while the MMP-8 and MMP-9
levels in non-pregnant women were 0.34 ng/ml and 2.09 ng/ml respectively. The
periodontal parameters in pregnant women were significantly elevated as compared to
non-pregnant women. The mean PPD, PS and GBI in pregnant women were 4.38mm ±
0.82, 49.7% ± 13.72 and 47.5% ± 12.90 respectively whilst in non-pregnant were 4.16 ±
0.22, 37.4 ± 18.07 and 35.4 ± 14.50 respectively. Our study concluded that all periodontal
parameters were elevated, while salivary inflammatory marker MMP-8 and MMP-9 levels
remained low in pregnant group as compared to non-pregnant group and there was no
association found between periodontal parameters and salivary levels of MMP-8 and
MMP-9 of pregnant women.
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