Hamid, Wan Zuraida Wan Ab. and Musa, Mustaffa and ldris, Fauziah Mohd ldris and Bhaskar, Shalini
(2011)
A study of lymphocyte subsets,
activation markers and herpers
viruses infection in epileptic
patients in HUSM.
Other.
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia.
(Submitted)
Abstract
Epilepsy is a chronic brain disorder that affects more than 50 million people throughout the
whole world. The cause of more than half of the sufferers remains unknown (idiopathic),
while the rest may have epilepsy due to certain causes of head injury, stroke, drugs
withdrawal or other identifiable problems. The prevalence of this disease increases annually
persuading researchers to find out the possible relations to these idiopathic epilepsies.
Previous reports suggested that there could be some kind of association between virus
infection and lymphocyte-mediated immunity leading to seizures and therefore this study is
conducted 1) to compare mean of lymphocyte subsets between epileptic patients and
healthy controls, 2) to compare mean of activated C04+ and cos• T cell subsets between
epileptic patients and healthy controls, 3) to determine the sociodemographic factors and
lymphocyte subsets in epileptic patients and 4) to observe the associations between lgG,
lgM in herpes viruses with lymphocyte subsets In epileptic patients.
A total of 190 subjects were enrolled in this study, 95 subjects for each group of healthy
controls and epilepsy patients. Subjects recruited fulfilled the inclusion and exclusion
criteria. Whole blood and serum samples were tested by flow cytometry and indirect ELISA
technique. Statistical analyses were performed using the SPSS version 12.0.
Results revealed that the number of NK cells (C016•s6•) were significantly higher in epileptic
patients (95%CI: -0.141,-0.002; p value: 0.042) while the number of activated T cells
(cos•co2s•) were significantly lower (95%CI: 0.034, 0.222; p value: 0.008) compared to
healthy controls. Patient education level (OR: 0.227; 95%CI: 0.127; 0.404; p value: 0.001),
the number of C016.56+ (OR: 8.759; 95%CI: 1.643; 46.685; p value: 0.011) and the number
of co4•co2s• (OR: 0.229; 95%CI: 0.092 ;0.571; p value: 0.002) were the only parameters
that were significantly associated with epilepsy. No significant correlation observed
between lymphocyte subsets and herpes viruses infection, however Cytomegalovirus (CMV)
lgG shows a significant difference in epileptic patients as compared to healthy controls (p
<0.001).
This study may suggest that the divergence in NK cells and activated cos• T cells
(Cos•co2s•) provides the idea that epilepsy patients has an immune disorder, whereas,
previous CMV infection may play a great role in contributing to epilepsy.
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