Daud, Mohd Khairi Md and Rahman, Normastura Abd and Zainuddin, Zafarina
(2009)
Study on the gjb3 and gjb6 gene
mutations among Malays with nonsyndromic
hearing loss.
Study on the gjb3 and gjb6 gene mutations among Malays with nonsyndromic hearing loss.
(Submitted)
Abstract
Hearing loss is the most common sensory disorder in human. Previous journals reported that
GJB2 gene is the most important gene involved in non-syndromic hearing loss; and GJB6 gene is
the second most which contributed to. This study is to screen mutations in GJB2 and GJB6 gene
among Malay patients with non-syndromic hearing loss. Ninety one patients and equal number
of normal hearing subjects were recruited for this study after getting informed consent. DNA
samples were collected using sterile buccal swab. After DNA extraction, genomic DNA was
amplified then screened using dHPLC technique. Certain samples were sequenced to confirm the
type of mutation. The result showed that only a few samples having mutations in GJB2 gene,
while no sample having mutation of GJB6 gene.
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