Siti Nor Ashrah, Zahari
(2006)
"A Study Of
Rh Positive Phenotypes I Genotypes Frequency Among Regular
Blood Donors Of Different Ethnic Group In Hospital Usm, Kelantan".
Other.
Universiti Sains Malaysia.
(Submitted)
Abstract
This study was perform in the Transfusion Medicine Unit of HUSM among 200
individuals from two major ethnic groups of Malay and Chinese regular blood donors of
both sexes and different of age groups. The aims of this study was to determine the
frequency of Rh positive phenotypes and genotypes among regular blood donors of
Hospital University Sains Malaysia (HUSM). The frequency of Rh genotypes were
determined by standard serological techniques. In this study nine phenotypes were found
to occur in the Malay and Chinese populations. In the Malay population (n=IOO), there
were seven phenotypes detected. The commonest phenotype in the Malay population was
CCDDee ( Rl Rl) with the frequency of 62%. This is followed by CcDDEe (Rl R2) 19%,
CcDdee (Rlr) 8%, CCDDEe (RJRz) 8%, ccDDEe ( R2r) 3%, CcDDEE (R2Rz) 2%
respectively. The rarest phenotype in Malay population is ccDdee (Ro r) with the
frequency of only 1%. The findings were different with the Chinese population where the
rarest phenotype is CCDDEE (RzRz) with the frequency of 1% which was not present in
the Malay population, like wise the ccDdee (Ro r) phenotype, it not present in the
Chinese population. This was followed by ccDDEe (R2r) 2% , CcDdee (Rlr) 4%,
CCDDEe (Rl Rz) 5%, and ccDDEE (R2R2) 9% respectively. The R2R2 phenotype was
found to be present only in the Chinese population with quite high frequencies and was
absent in the Malay population. The commonest phenotype in Chinese, CCDDee ( Rl Rl)
with the frequency of 55% and followed by CcDDEe (RJR2) with frequency of 24%
respectively. This kind of study should be on going and should be also extended to other
categories of blood donors among other ethnic groups in Malaysia in view of keeping
proper record of regular blood donors.
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