Iberahim, Salfarina
(2018)
Haemostatic, inflammatory and haematological biomarkers among orthopaedic patients with prolonged immobilization and risk of venous thromboembolism.
Masters thesis, Universiti Sains Malaysia.
Abstract
Trauma and prolonged immobilization induce hypercoagulable state with thrombotic
potential. Multiple studies have shown close relationship between haematological,
haemostatic & inflammatory markers and post traumatic patients.
The aims of this study were to investigate the changes of hypercoagulable markers
(haemostatic, inflammatory and haematological parameters) in prolonged immobilized
trauma patients and to determine the correlation between haemostatic parameters and
inflammatory parameters (ESR, CRP) among the subjects. The association between
clinical risk factors (age, sex, BMI, smoking and type of injury) and the abnormal
laboratory parameters were also studied including the relationship with VTE.
A prospective cohort study was conducted at Hospital University Sains Malaysia from
September 2016 to July 2017. A total of 52 patients with lower limb/s fracture with age
ranged from 12 to 59 years old, who required immobilization more than 7 days and
received no anticoagulant prophylaxis were involved in this study. The predetermined
parameters were serially measured on day 1 and day 8 of immobilization. The
laboratory tests included PT, aPTT, D-dimer, Fibrinogen, AT, Protein C, Protein S,
ESR, CRP and platelet count. Subjects’ characteristic and clinical risk factors (age, sex,
BMI, smoking and type of injury) were recorded.
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