Sang, Chong Yuen
(2020)
A two-year retrospective study on hepatitis b cases in Hospital Universiti Sains Malaysia (HUSM) from 2018-2019.
Masters thesis, Universiti Sains Malaysia.
Abstract
Hepatitis B virus (HBV) infection is a deadly infectious disease worldwide.
HBV infection is predominantly high in endemic region which includes Southeast Asia
(SEA). Malaysia is one of the endemic country in SEA and has higher incidences of
hepatitis B (HB) infection. Given that, there is a paucity of information on
epidemiological trend and patient clinical data, therefore the goal of this project is to
analyze HB cases reported to Hospital USM, Kubang Kerian, Kelantan. Although data
was collected from a single hospital, the catchment area of this hospital is large as most
patients from Kelantan state are referred or walk in into this hospital for diagnosis and
treatment. Data were extracted from the hospital information system and exported into
Microsoft excel and were analysed using SPSS software version 26.
There are total 232 HB patients are newly diagnosed and on-going follow up in
Hospital USM from 2018 until 2019 were the subjects of this research study. Of that,
65% of HB patients were males and most patients were in the economically productive
age group between 30 to 60 years old. Regarding ethnicity, most of the patients are
Malays followed by Chinese and Indians. Besides that, majority of the HB patients were
non-healthcare workers and retired group. The clinical data of HB indicated more
patients were chronically infected with HB than acute. The common treatment that were
administered to chronic HB patients are antiviral drugs (AVT) and interferons (IFN).
Both are standard of care treatment for chronic hepatitis B (CHB) infection.
Nevertheless, the univariate analyses were included in this research study. From the
analyses, we manage to establish an association between age and other sociodemographics
distributions only for HB patient gender, phase of infection and
complication of HB infection. The risk factors of HB infection included in this study
were age, gender and ethnicity. The results shown that, there is not statistically
significance in these risk factors.
Given the data obtained in this study were secondary data, some of the data are
not available and might not be updated from time to time. Thus, it is not comprehensive
enough to reflect the prevalence of hepatitis B cases in Malaysia. On-going study is
crucial to overcome the limitation in this project and establish of the epidemiological
data of hepatitis B infection would be important for public health information.
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