Rehman, Asia
(2006)
Studies to investigate the prevalence of estrogen
receptor polymorphism & its association
alveolar bone loss & early tooth loss in
postmenopausal women.
Documentation.
Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia.
(Submitted)
Abstract
Depletion of estrogen production and secretion in postmenopausal women may lead to
rapid bone loss and decreased bone mineral density (BMD). Decreased systemic BMD
may also affect oral bone particularly mandibular bone resorption. Although several
environmental factors influence bone loss, genetic contribution particularly estrogen
receptor gene (ERG) polymorphism had been reported.
The objectives of this study were to investigate the distribution of ERG polymorphisms
in postmenopausal Malay women (PMW) and to detect the association of the
polymorphisms to alveolar bone resorption. Sixty four PMW were recruited from the Out
Patient Dental Clinic, Hospital Universiti Sains Malaysia, Kelantan. Oral examination
and alveolar bone resorption measurement were performed on these study subjects.
Genotyping was done through the restriction cleavage of polymerase chain reactionamplified
genomic DNA with the two restriction enzymes, Pvull and Xbal. Estrogen
receptor genotypes were represented as P or p (Pvull) and X or x (Xbal) with the lower
case letters signifying the presence of the restriction site.
The results of this study indicated a high frequency of heterozygous allelic variant (PpXx)
in PMW. However no significant association between ERG polymorphisms and alveolar
bone resorption was observed. Therefore ERG polymorphisms may not be a genetic
marker for the alveolar bone resorption in PMW.
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