Study on the effectivenss of nebulized fentanyl citrate as modality of analgesia in children with acute pain

Yahaya, Raden Nezarul Raden (2018) Study on the effectivenss of nebulized fentanyl citrate as modality of analgesia in children with acute pain. Masters thesis, Universiti Sains Malaysia.

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Introduction: To assess the effectiveness of nebulized fentanyl citrate in treating children presenting with acute severe pain of various aetiologies. Methods: Patients aged 5 to 15 years old presented with acute severe pain of any causes were enrolled into the study through convenient sampling and received intravenous preparation of fentanyl citrate at dose of 4 mcg/kg administered through oxygen driven nebulizer circuit. Pain scores were assessed at pre-treatment and subsequently at 5 minutes interval until 60 minutes post-treatment using Wong and Baker faces pain scale. Vital signs and potential adverse events were also monitored. Results: 42 children with acute pain of various causes participated in this study and tolerated the nebulized fentanyl citrate well. 2 patients were withdrawn due to insufficient pain control post treatment. The pain aetiologies were categorized into fractures (n=14), soft tissue injuries (n=15) and abdominal pain (n=11). The mean pain score at 10 minutes on nebulized fentanyl administration decreased by 2.65 (95% CI 2.62 to 2.73) from the baseline. Pain score continued to decrease at 15 minutes (mean pain score difference 4.20; 95% CI 4.01 to 4.39) followed by a sustained plateau pain score at 20 minutes until 60 minutes. The pain score reduction at alltime intervals measured post-treatment were highly significant (P <0.001). No adverse events or vital signs deterioration observed following nebulized fentanyl. Conclusion: Nebulized fentanyl citrate at dose of 4 mcg/kg given through oxygen drive nebulizer circuit was effective in treating children with acute severe pain without causing adverse events and should be considered as a modality of acute pain treatment in children population.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Fentanyl
Subjects: R Medicine > RD Surgery
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 03 Nov 2020 08:21
Last Modified: 03 Nov 2020 08:22

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