Hassan, Noor Hasliza
(2006)
A study on the effect of oral hypoglycaemic agents on arterial stiffness among malay patients with type 2 diabetes mellitus.
Masters thesis, Universiti Sains Malaysia.
Abstract
Objective : The purpose of this study is to see whether there was any significant
difference in arterial stiffness (as measured by augmentation index) between diabetic
and non diabetic subjects and to see whether there was any significant difference
between two different oral hypoglycaemic agents(OHA) regimens, (sulphonylurea
monotherapy and metformin in combination with sulphonylurea therapy) on arterial
stiffness.
Methods : This was a case control study conducted in the Klinik rawatan
keluarga(KRK) and Diabetic clinic, HUSM from May 2004 till May 2005. Hundred
and two diabetic subjects and hundred and two age- and sex-matched non-diabetic
control subjects were recruited after obtaining verbal consent following explanation of
study protocol. Augmentation index (AI) was measured using the Sphygmocor
apparatus and all measurements were performed by the researcher after an earlier
validation study. These mean augmentation index measurements were then analyzed.
Result : The mean of AI of diabetic subjects was significantly higher than non
diabetic subjects ( 140.32 ± 12.0% Vs 128.77 ± 10.69%, P < 0.0001 ). However, therewas no significant difference in mean AI between two different OHA regimen groups
in diabetic subjects (140.51 ± 11.42 Vs 140.14 ± 12.86, 95% CI: -4.40, 5.15, p =
0.877).
Conclusion: Diabetic patients have increased arterial stiffness compared with age- and
sex-matched non diabetic subjects, which may partly explain why diabetes mellitus
are associated with increased cardiovascular risk. This study also showed that two
different groups of oral hypoglycaemic agents have no effect in relation to arterial
stiffness.
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