The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways

Khan, Md Shamsuddin Sultan (2017) The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways. PhD thesis, Universiti Sains Malaysia.

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Abstract

In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells. Antiangiogenic activity was investigated with tube formation, CAM, and aortic explant assays. The compounds’ activity in IL17A and VEGF expression was determined using ELISA and their apoptotic activity was assessed by the Caspase assay. The cancer pathway was determined using the reporter gene assay.

Item Type:	Thesis (PhD)
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User:	Mr Aizat Asmawi Abdul Rahim
Date Deposited:	22 Oct 2020 08:34
Last Modified:	22 Oct 2020 08:34
URI:	http://eprints.usm.my/id/eprint/47701

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