Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action

Varghese, Christapher Parayil (2017) Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action. PhD thesis, Universiti Sains Malaysia.

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Abstract

Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 induced acute hyperlipidemia in rats. Atorvastatin (60 mg/kg) was used as standard drug. The study showed that both extracts reduced the total cholesterol (TC), triglycerides (TG), LDL, VLDL, atherogenic index, and increased HDL levels when compared with hyperlipidemic control and the effect was higher in methanol extract when compared to aqueous extract.

Item Type: Thesis (PhD)
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User: Mr Aizat Asmawi Abdul Rahim
Date Deposited: 21 Oct 2020 07:20
Last Modified: 21 Oct 2020 07:20
URI: http://eprints.usm.my/id/eprint/47652

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