The effect of autogenous nonvascularised periosteum transplantation on bone healing - an animal study

Azid, Azuhairy (2006) The effect of autogenous nonvascularised periosteum transplantation on bone healing - an animal study. Masters thesis, Universiti Sains Malaysia.

PDF - Submitted Version
Download (3MB) | Preview


The purpose of this study 1s to evaluate the effect of Fresh Frozen allograft on a large-sized tibia defect 111 a rabbit model when a non vascularised periosteum sleeve is wrapped around it. This is an animal experiment, a pilot study and descriptive in nature carried out in MEDICAL SCHOOL. UNIVERSITI SAINS MALAYSIA, KUBANG KERIAN KELANTAN. A total of 12 matured ma le rabbits were used. Nine( 9) rabbits were divided into three groups (A,B,C) and three (3) other rabbits were used as control group (group D). A 3 em segment of the (R) tibia shaft was removed and the defect was then replaced with bare allograft and stabil ized with Kirschner wire (K wire) s ize 2 mm. The leg was immobilised with Plaster of Paris. In the groups A,B and C the a llogra ft segments were wrapped circumferentially by the free non-vascularised periosteal flap that was harvested from the (L) tibia. The rabbit mode l in group D had allograft transplantation only without the incoorperation of free autogenous nonvascularised periosteal transplantation. At the end of 211 d, 41 h and 61 h weeks the rabbits from each of these groups were X rayed. The plain C.T scan of the (R) T ibia were taken and later with infusion of IN radio opaque dye. These procedures were be ing done under general anaesthesia. The results observed m the rabbits where there were periosteum used to wrap around the entire segment of allografts, there were union at both ends of the allografts seen at the end of 4th and 6th weeks. At the end of 2nd week both ends of the allograft were still seen not united, but some callus was seen to form at the fracture ends. However at the end of 61 h weeks, beside a good union that was observed at the host-graft junctions, there were solid callus seen encasing the whole allograft segments. But in a control group where the allograft segments were left bare without periosteum transplant, there were no callus form surrounding the allograft segments. Union at the both ends of the allograft segment have not occurred at the end of 2nd , 4th weeks and at the end of 6th week the allograft was seen to fragment and telescope into the medullary cavity of the host. In conclusion, the free non - vaseularised periosteum transplantation modified the healing ofallogral1 and maintained the intergrity ofthe allograft.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Tibia
Subjects: R Medicine > RC Internal medicine
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 13 Sep 2020 08:36
Last Modified: 13 Sep 2020 08:36

Actions (login required)

View Item View Item