Ismail, Che Shuraya Che
(2005)
In vitro effect of ganoderma lucidum
extracts on hematological parameter.
Masters thesis, Universiti Sains Malaysia.
Abstract
Thrombosis is a pathologic condition that occurs when the body forms
arterial or venous blood clots that are excessively large and obstruct blood flow.
Heart attack, stroke or pulmonary embolism are examples of conditions when
develop in blood vessels which may contribute to various symptoms and
complications. Therefore the search for an effective agent that can secure full
antithrombotic benefits while minimizing the antihaemostatic outcome should be
pursued. In this study, in order to assess the effect of Ganoderma lucidum in
inhibition of platelet aggregation, two types of extract were prepared from crude
powder of commercially available products of Ganoderma lucidum. Both the two
types of extracts were tested for their activities on blood cells in vitro. The effects of
this mushroom were tested based on the changes in hematological parameters
following the treatment with different doses of water and ethanol extract
Ganoderma Jucidum using hematology analyzer (Abbott Celldyn 4000). The test
duration for the observation was set for 2 hours and the observation were made
every 30 minutes intervals. From this study, the results showed that there were no
significant difference of effect between different doses of water and ethanol
extracts on MPV. However, there were significant differences of the effect of
extracts of Ganoderma lucidum in different concentration on MPV at different time
intervals. Antiplatelet aggregation activities by indirect evaluation of changes in
blood cells parameters in vitro following the treatment with Ganoderma Jucidum
extract may not be fully explored or elucidated by the in vitro study. However, theresults from this preliminary study will assist in establishing the direction of an in
vivo study, which will be followed. In order to look at the activities of platelet and
the effects on other hematological parameters in vivo, a long-term prospective
study should be explored to prove the potential use of Ganoderma lucidum
mushroom as a prophylactic agent for prevents arterial thrombosis.
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