Ismail, Shatriah and Ibrahim, Mohtar and Ghani, Zulkifli Abd
(2006)
A randomized comparison on the corneal
endothelial morphology after the use of 2
different viscoelastic agents during
phacoemulsification surgery.
A randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgery.
(Submitted)
Abstract
Objective: To compare corneal endothelial morphological changes after the use of
Healon 5 (sodium hyaluronate 2.3%) and Healon GV (sodium hyaluronate 1.4%) during
phacoemulsification surgery, particularly at three months after the surgery.
Settings: Department of Ophthalmology, School of Medical Sciences, Universiti Sains
Malaysia, Malaysia and Eye clinic, Hospital Kota Bharu, Kelantan, Malaysia.
Materials and Methods: One hundred and ten patients were randomized, 55 per group,
in a prospective randomized clinical trial of phacoemulsification surgery using Heal on 5
or Heal on GV. Three ophthalmologists performed the surgeries. The corneal endothelial
cells density, average cell size, coefficient variation and hexagonality were assessed
preoperatively and at three months postoperatively using a non-contact specular
microscope Topcon SP2000P. Analysis of the data was performed using SPSS version
10.0, Independent-Samples T Test.
Results: There was statistically significant difference between Healon 5 group and
Healon GV group based on endothelial cell density (p=0.015) and percentage of cell loss
(p=0.033). The cell size was noted significantly smaller in the Healon 5 group compared
to the Healon GV group at three months (p=0.004). A similar result was also noted in
percentage of changes in cell size (p=0.033). There were no statistically significant
differences in changes of coefficient variation of cell size and hexagonality in both
groups at three months after the surgery.
Conclusion: Minimal corneal endothelial morphological changes were noted in the
Healon 5 group compared to the Healon GV group, particularly in term of less cell loss
and less alteration in cell size at three months after the surgery. Thus, indicates that
Healon 5 is more effective than Healon GV in minimizing risk of corneal endothelial
injury during phacoemulsification surgery.
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