Hussain, Nik Hazlina Nik
(2004)
A study on factors affecting newborn weight
and large for gestational age newborns
in non-diabetic mothers:
The role of maternal serum triglycerides.
A study on factors affecting newborn weight and large for gestational age newborns In non-diabetic mothers: The role of maternal serum triglycerides.
(Submitted)
Abstract
Introduction: Triglycerides have been shown to be a biochemical predictor of newborn
weight and risk of large for gestational age (LGA) in a few previous small studies. The
objective of this study is to ascertain whether mid-pregnancy fasting serum triglycerides
can predict the risk of developing LGA and newborn weight in non-diabetic pregnant
mothers.
Methodology Universal sampling of pregnant mothers attending the antenatal clinic at
the Hospital Universiti Sains Malaysia (HUSM) and nearby clinics between 24 to 32
weeks gestation was carried out between December 2003 and July 2004. Expectant
mothers were screened for exclusion criteria including diabetes, hypertension, preeclampsia, fetal anomaly and multiple gestations. Those who were sure of dates and
consented for the study were enrolled. Modified ora.l glucose tolerance test (MOGTT)
was performed and fasting serum triglycerides and total cholesterol were analysed. The
subjects were followed up at delivery when the period of gestation, the birth weight and
the sex of newborn were noted. The correlations of the variables with newborn weight
were tested and multiple linear regressions were used to find the associations. Bivariate
logistic regression was used to look at the association of LGA newborn and the
variables including triglycerides which were divided into two groups. The associations of
the two groups of triglycerides and fasting plasma glucose (FPG) with the incidence of
LGA were tested in cross tabulations.
Results: A total of 310 subjects were enrolled and 267 completed data were analyzed,
246 were normal glucose tolerant (NGT) and 21 impaired glucose tolerant (IGT). The
incidence of IGT in this study was 7.9%. In NGT, triglycerides correlated poorly (r-0.14,
p=0.03) with newborn weight while maternal body mass index (BMI) (r-0.30, p<0.001)
and FPG (r-0.28, p<0.027) were the only two variables moderately correlated with
newborn weight after adjustment of the gestation and gender of the newborn. FPG (OR
3, p=0.027), high triglycerides value (>2.78mmoi/L) (p=0.039) and 2 hours postprandial
plasma glucose (HPPPG) (p=0.044) were associated with risk of LGA newborn. With
high triglycerides (>2.78mmoi/L) and FPG (>4.3mmoi/L), risk of getting LGA was 31.8o/o
(p<0.001).
Conclusions: In NGT subjects, mid-pregnancy high FPG and high triglycerides value
could be used to predict risk of getting LGA newborn.
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