Sulaiman, Siti Amrah and Kapitonova, Marina Yu and Jamalullail, Syed Mohsin S.
(2005)
The effects of an indigenous contraceptive herbal
Formulation on the gonadotrophs of the pituitary gland
Of rat (experimentat immunohistochemical research).
The effects of an indigenous contraceptive herbal Formulation on the gonadotrophs of the pituitary gland Of rat (experimentat immunohistochemical research).
(Submitted)
Abstract
Objective: To observe the morphometric changes of the gonadotrophs and the plasma
concentrations of follicle stimulating hormone and leutinizing hormone.
Methodology : Thirty five animals were randomly divided into 5 groups. Control animals
were given vehicle and experimental animals were given combined herbal extract or
individual herbal extract at a dose of 540 mg/kg/day s.c for 7 days. Immune-stained
gonadotrophs were studied by using image analyzer, FSH and LH serum concentrations
were determined.
Results: The FSH and LH concentrations were low in animals that received combined
herbal extract (p<0.01) . FSH concentration was noted to be significantly low in animals
that received P. rotundifolia (p<0.05). The mean cell area and cell density of
gonadotrophs of animals that received combined herbal extract were significantly low
compared to control group (p<0.05).
Discussion : These findings were corresponded to our previous findings that the
combined herbal extract reduced both estradiol and progesterone concentrations and
the individual plant extracts reduced the estradiol concentration significantly but not the
progesterone.
Conclusion: We concluded that the herbal extracts do affect the pituitary gonadotrophs
and the circulating gonadotrophins. Further evaluation is needed to verify whether the
effect was directly on the pituitary or through a higher centre such as the hypothalamus.
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