Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing

Zainol, Nor Azah (2014) Development And Characterization Of Eugenol In Cinnamon Leaf Oil Nanocream For Wound Healing. Masters thesis, Universiti Sains Malaysia.

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Cinnamon (Cinnamomum zeylanicum) leaf oil contains high percentage of eugenol and has antimicrobial, antioxidant and anti-inflammatory activities. However, the undiluted oil can cause irritation to the skin. Therefore, to avoid irritation cinnamon leaf oils was formulated into nanocream. The nanocream base was prepared using palm oil, buffer pH 5.5 and surfactants (Tween, Span and Carbitol) at different HLB values of 13.71, 11.13, 9.84 for Tween 80 and Span 65 while 13.92, 12.84 and 10.68 for Tween 80 and Carbitol. Fifteen nanocream base formulations were selected from nanocream areas in three pseudo-ternary phase diagrams, and tested for accelerated stability study. Only four formulations passed the test, and these formulations were modified by adding 2 % cetostearyl alcohol as thickening agent, to improve their stability. The modified formulations were also subjected to accelerated stability test and three formulations passed the test. The nanocream base formulations were characterized in term of droplet size, zeta potential, apparent viscosity, and rheological properties. It was found that the nanocream base B2(2) was the best formulation and 2% cinnamon leaf oil was incorporated to this formulation. The optimized cinnamon leaf oil formulation consists of buffer pH 5.5, oil (96% palm oil, 2% cinnamon leaf oil and 2% cetostearyl alcohol) and surfactants (70% Tween 80 and 30% Span 65 with HLB value 11.13) at the ratio of 47.4:15.8:36.8.

Item Type: Thesis (Masters)
Additional Information: Access full text: Off Campus Log In Via OpenAthens
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User: Mr Mohammad Harish Sabri
Date Deposited: 05 Mar 2020 08:40
Last Modified: 05 Mar 2020 08:40

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