Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia

Mohammed, Omar Saeed Ali (2013) Anti-Neoplastic Studies Of Standardized Root Extract Of Eurycomal Longifolia (Taf273) Towards Leukaemia. PhD thesis, Universiti Sains Malaysia.

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Abstract

The anti-neoplastic activity of root extracts from Eurycoma longifolia was investigated towards leukaemia using in vitro and in vivo models. Four partially purified sub-fractions (F1, TAF273, F3 and F4) derived from resin chromatography of the crude methanolic extract of E. longifolia roots were screened for the anti-leukaemic, anti-angiogenic and anti-oxidant activities. The in vitro anti-leukaemic activity was tested using K-562, HL-60 and Kasumi-1 leukaemic cell lines whereas in vivo anti-leukaemic activity was tested using K-562-xenograft mice model. The toxicity, mechanism of action and drug combination effect of TAF273 were also investigated.

Item Type: Thesis (PhD)
Additional Information: Access full text: Off Campus Log In Via OpenAthens
Subjects: R Medicine > RK Dentistry > RK1-715 Dentistry
Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Video
Depositing User: Mr Mohammad Harish Sabri
Date Deposited: 12 Feb 2020 07:59
Last Modified: 12 Feb 2020 07:59
URI: http://eprints.usm.my/id/eprint/46191

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