Fahrurazi, Fairul Ezwan
(2018)
The association patterns between socio-demographic, clinical and treatment-related characteristics in multidrug-resistant tuberculosis patients in Malaysia.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: The emergence and increasing number of multidrug-resistant tuberculosis
(MDR-TB) worldwide have posed new threats to public health locally and globally. There are
a number of important patient’s characteristic for MDR-TB. However, there are no studies
published about association between the characteristics of MDR-TB patient in Malaysia.
Objective: The objective of this study was to describe the socio-demographic, clinical and
treatment related characteristics of MDR-TB patients in Malaysia and to determine the
association patterns between the characteristics of MDR-TB patients in Malaysia
Methods: Analysis of secondary data from a cross-sectional design study on registry of
Tuberculosis Information System (TBIS) of Ministry of Health Malaysia. Socio-demographic,
clinical and treatment related characteristics of MDR-TB patient were extracted from the
databases. Log-linear regression was used to identify association patterns between the
characteristics with odd ratios and 95% confidence interval.
Results: There were 395 cases of MDR-TB reported across Malaysia from 2012 to 2016. Odds
of immigrant were 77% lower in old age than young age (OR = 0.23, 95% CI: 0.11, 0.43).
Odds of male gender were 2.37 times in old age group than young age group. (OR = 2.37, 95%
CI: 1.45, 3.95). Odds of male gender were 5.22 times in HIV positive status group than
negative HIV status (OR = 5.22, 95% CI: 1.48, 33.12). Odds of previous TB treatment were
78% higher in male than female (OR = 1.78, 95% CI: 1.13, 2.82) and 52% lower in positive
sputum status than negative sputum status (OR = 0.48, 95% CI: 0.30, 0.78).Conclusion: Log-linear analysis revealed that there are association between age category and
immigrant status, age category and gender, gender and HIV, gender and history of previous
TB treatment, and history of previous TB treatment and sputum status.
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