Ismail, Shaiful Bahari and Noor, Norhayati Mohd and Hussain, Nik Hazlina Nik and Sulaiman, Zaharah and Shamsudin, Muhammad Asyraf and Irfan, Muhammad
(2019)
Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of
randomized control trials.
Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of randomized control trials.
(Submitted)
Abstract
Erectile dysfunction is common in adult men, particularly those with hypertension and diabetes. The present study
determines the effectiveness of angiotensin receptor blocker (ARB) drugs on erectile function in hypertensive male
adults. For this purpose, CENTRAL and MEDLINE and reference lists of the articles were searched. The randomized
controlled trials (RCTs) were selected that compared ARBs with conventional therapy or no treatment in men of any
ethnicity who were presented with hypertension and/or diabetes. A total four trials that had 2,809 men were included.
Three trials reported adequate random sequence allocation, two reported adequate blinding. Attrition bias is low in
one of the included studies. All three studies are of low risk of selective reporting bias. There was an improvement in
sexual activity with ARBs (valsartan) (mean difference (MD): 0.71, 95% Confidence Interval (CI) 0.66 to 0.76, I2 statistic
= 0%). However, the erectile functions did not increase significantly in ARBs (losartan or telmisartan) treated men as
compared to control or placebo (n = 203 vs n = 232; MD: 1.36; 95% CI: −0.97 to −3.69; I2 statistic = 80%). These
results suggested that ARBs significantly improved sexual activity among hypertensive men. However, the erectile
function was not significantly improved in ARBs treated men as compared to the control or placebo-treated. There
were limited studies available. Hence, additional studies are needed to support findings from this review. ARBs should
be considered when prescribing antihypertensive drugs to men.
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