Factors associated with breast cancer and role of nutritional status on serum high-molecular weight adiponectin

Rashid, Ainaa Almardhiyah Abd (2018) Factors associated with breast cancer and role of nutritional status on serum high-molecular weight adiponectin. Masters thesis, Universiti Sains Malaysia.

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Breast cancer is the leading killer of women in Malaysia. Nutritional status and adiponectin are modifiable risk factors for breast cancer occurrence that can be efficiently targeted. The purpose of this study was to determine the associated factor of breast cancer and relationship between nutritional status and high molecular weight (HMW) adiponectin. This was a case- control study, conducted from January 2014 until August 2015 at Hospital Universiti Sains Malaysia (HUSM) and Universiti Sains Malaysia (USM). Untreated breast cancer cases (n=55) were assigned as cases, and healthy controls (n=58) who were staff at HUSM and USM acted as controls. Sociodemographic and reproductive data were obtained with a standard questionnaire and dietary data was obtained from validated diet history questionnaire (DHQ). Anthropometric assessments (weight, height, hip, waist circumference (WC) and body fat composition) were measured and overnight fasting venous blood samples were analysed for lipid profiles, plasma glucose, insulin, high sensitivity C reactive protein (hs-CRP) and HMW adiponectin. Physical activity was measured using accelerometer for 2 weekdays and 1 weekend. Simple logistic regression found these factors associated with breast cancer risk: sociodemographic (age, lower education level, exposed to secondhand smoke, lower monthly household income), physical examination (systolic blood pressure, diastolic blood pressure, pulse, more than 1 year of traditional medicine) and nutritional status (WC, HDL cholesterol, TG, blood glucose and sugar intake). Multiple logistic regression wasperformed to determine factors associated with breast cancer risk. The predictors of breast cancer development were exposed to secondary smoke (OR=10.00, [95% CI: 2.42, 41.30]), monthly household income of less than RM 2,300 (OR=18.05, [95% CI: 2.56, 127.10]) and systolic blood pressure (OR=1.08, [95% CI: 1.04, 1.12]). Multiple linear regression analysis revealed that there was a significant linear negative relationship between WC and HMW adiponectin (β=-0.05; p=0.005) among breast cancer cases. Besides, HDL cholesterol was positively associated with HMW adiponectin (β=1.83; p=0.010) among breast cancer cases. BMI was negatively associated with HMW adiponectin (β=-0.02; p=0.001) among healthy controls. This study indicated the potential role of modifiable risk factor in the occurrence of breast cancer.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Breast neoplasms
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 27 Nov 2019 04:04
Last Modified: 04 Dec 2019 02:55
URI: http://eprints.usm.my/id/eprint/45800

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