Rashid, Ainaa Almardhiyah Abd
(2018)
Factors associated with breast cancer and role of nutritional status on serum high-molecular weight adiponectin.
Masters thesis, Universiti Sains Malaysia.
Abstract
Breast cancer is the leading killer of women in Malaysia. Nutritional status
and adiponectin are modifiable risk factors for breast cancer occurrence that can be
efficiently targeted. The purpose of this study was to determine the associated factor
of breast cancer and relationship between nutritional status and high molecular
weight (HMW) adiponectin. This was a case- control study, conducted from January
2014 until August 2015 at Hospital Universiti Sains Malaysia (HUSM) and
Universiti Sains Malaysia (USM). Untreated breast cancer cases (n=55) were
assigned as cases, and healthy controls (n=58) who were staff at HUSM and USM
acted as controls. Sociodemographic and reproductive data were obtained with a
standard questionnaire and dietary data was obtained from validated diet history
questionnaire (DHQ). Anthropometric assessments (weight, height, hip, waist
circumference (WC) and body fat composition) were measured and overnight fasting
venous blood samples were analysed for lipid profiles, plasma glucose, insulin, high
sensitivity C reactive protein (hs-CRP) and HMW adiponectin. Physical activity was
measured using accelerometer for 2 weekdays and 1 weekend. Simple logistic
regression found these factors associated with breast cancer risk: sociodemographic
(age, lower education level, exposed to secondhand smoke, lower monthly household
income), physical examination (systolic blood pressure, diastolic blood pressure,
pulse, more than 1 year of traditional medicine) and nutritional status (WC, HDL
cholesterol, TG, blood glucose and sugar intake). Multiple logistic regression wasperformed to determine factors associated with breast cancer risk. The predictors of
breast cancer development were exposed to secondary smoke (OR=10.00, [95% CI:
2.42, 41.30]), monthly household income of less than RM 2,300 (OR=18.05, [95%
CI: 2.56, 127.10]) and systolic blood pressure (OR=1.08, [95% CI: 1.04, 1.12]).
Multiple linear regression analysis revealed that there was a significant linear
negative relationship between WC and HMW adiponectin (β=-0.05; p=0.005) among
breast cancer cases. Besides, HDL cholesterol was positively associated with HMW
adiponectin (β=1.83; p=0.010) among breast cancer cases. BMI was negatively
associated with HMW adiponectin (β=-0.02; p=0.001) among healthy controls. This
study indicated the potential role of modifiable risk factor in the occurrence of breast
cancer.
Actions (login required)
 |
View Item |
