Magosso, Enrico
(2011)
Evaluation Of The Hepatoprotective Effects Of Tocotrienols An The Relationship Between Non-Alcoholic Fatty Liver And Brain White-Matter Lesions.
Masters thesis, Universiti Sains Malaysia.
Abstract
Non-alcoholic fatty liver disease is one of the most common liver disorders
worldwide. However, no data from systematic studies are available for Malaysia on
prevalence or rate of this disease.
In the present study 180 walk-in mildly hypercholesterolemic adults of both genders
were screened using ultrasound imaging to determine the presence of non-alcoholic
fatty liver. The rate of this hepatic disease was found to be high, since it was
diagnosed in almost 60% of the participants. Non-alcoholic fatty liver disease
consists of fat infiltration in the liver, at present no pharmacological treatment is
available.
The screening was part of the recruitment process for a double-blind placebocontrolled
study aimed at evaluating the activity of tocotrienols for the treatment of
non-alcoholic fatty liver disease. Tocotrienols, that are extracted from palm oil, are
members of the vitamin E family.
Evaluation of the effects of tocotrienols for treatment of non-alcoholic fatty liver
disease was performed by comparing liver echogenicity at baseline and at conclusion
of the study. Liver hyperechogenicity is proportional to the fat content.
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