Hitam, Wan Hazabbah Wan and Hoi, Tan Soon and Jaafar, Hasnan
(2004)
Comparison of conjunctival impression cytology between glaucoma
patients treated with topical
timolol maleate 0.5% and topicallatanoprost 0.005%.
Comparison of conjunctival impression cytology between glaucoma patients treated with topical timolol maleate 0.5% and topicallatanoprost 0.005%..
(Submitted)
Abstract
Introduction:
All topical medications are known to cause conjunctival reactions, and topical antiglaucoma
drugs are also no exception. Long term drug induced toxicity to the conjunctiva
is postulated to cause filtering bleb scarring and filtration surgery failure. Chronic
application of topical timolol maleate 0.5% and topical latanoprost 0.005% had been
shown to alter the morphology of the conjunctival ocular surface.
Objective:
To compare conjunctival surface morphological changes with the use of the topical
timolol maleate 0.5% and topicallatanoprost 0.005%.
Methodology:
Newly diagnosed glaucoma patients who met the selection criteria were randomly
divided into two groups. One group treated with topical timolol maleate 0.5%, another
group treated with topical latanoprost 0. 005%. Before the treatment was started, the first
conjunctival impression cytology was taken. After three months of treatment, the second
conjunctival impression cytology was obtained. The changes that occurred between thefrrst and second conjunctival impression cytology in the individual group were analyzed.
Conjunctival surface changes that occurred with the use of topical timolol maleate 0.5%
were also compared with the conjunctiva surface changes that occurred with the use of
topicallatanoprost 0. 005%.
Results:
There were thirty-nine newly diagnosed glaucoma patients included in this study. Twenty
patients were in the Timolol group and nineteen patients in the Latanoprost group. In
both groups of patients, there was no change of the conjunctival epithelial cell
morphology after three months of anti-glaucoma therapy. However, there was statistically
significant reduction of the goblet cell and mucous granule density in both groups of
patients after three months of the topical anti-glaucoma therapy (P- value <0.001). By
using the independent T -test, there was no significant difference of the goblet cell and
mucous granule density between the Timolol group and the Latanoprost group after three
months of treatment.
Conclusion:
This concludes that both timolol maeate 0.5% and topicallatanoprost 0.005% cause great
reduction of conjunctival goblet cells and mucous granules within three months of
treatment. However, the conjunctival epithelial cell morphology remained normal after
three month of treatment in both groups of patients. This study gives evidence that topical
timolol maleate 0.5% and topicallatanoprost 0.005% cause morphological changes ofthe
conjunctival surface after short term (three months) therapy. However, there was nodifference in the conjunctival morphological changes between the Timolol group and
Latanoprost group.
Actions (login required)
 |
View Item |
