Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase

Asaruddin, Mohd Razip (2016) Modelling And Syntheses Of Vanillin Derivatives Targeting Influenza Virus Neuraminidase. PhD thesis, Universiti Sains Malaysia.

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Abstract

Influenza remains a serious global threat. To date, zanamivir and oseltamivir used as NA inhibitors were reported to be resistant to influenza virus. Therefore, new and effective NA inhibitors must be discovered. In this study, pharmacophore modelling approach was used to search for NA inhibitors with new scaffold. Two computer softwares such as Discovery Studio 2.5 and LigandScout 3.1 was utilized. Through the softwares, the pharmacophore modelling approaches was generated. Ligand-based and structure-based pharmacophore modelling approaches will complement each other. Ligand-based pharmacophore modelling approach is based on common features functional groups.

Item Type: Thesis (PhD)
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User: ASM Ab Shukor Mustapa
Date Deposited: 13 Sep 2019 01:54
Last Modified: 13 Sep 2019 01:54
URI: http://eprints.usm.my/id/eprint/45418

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