Mahmood, Wan Haslindawani Wan
(2004)
A prevalence study of platelet alloantibodies in multiply
transfused thrombocytopenic patients in HUSM.
A prevalence study of platelet alloantibodies in multiply transfused thrombocytopenic patients in HUSM.
(Submitted)
Abstract
BACKGROUND: Multiply transfused patients are frequently subjected to platelet
alloimmunization. These platelet alloantibodies produced can result in refractoriness to
platelet transfusion.
STUDY DESIGN AND METHODS: Ninety five thrombocytopenic (platelet count
<1 00 x 1 09/1) and multilply transfused (more than 2 times transfusion of any blood
component with last transfusion more than 2 weeks prior to the study) patients were
recruited prospectively. The blood samples were tested using a Solid Phase system
(Capture P).
RESULTS: There were 45 males (47.4%) and 50 females (52.6%) recruited with ages
from 3 to 90 years. The frequency of transfusions ranged from 10-168. Seven patients
(7.4%) were detected to have platelet alloantibodies, predominantly anti-HPA-5b in 4
patients (4.2%). Three of them (3.2%) showed a non-specific pattern. Six patients (6.3%)
had received packed cells less than 20 units and another 1 (1.1%) received more than 20
units of packed cells. Four patients (4.2%) received platelet transfusion of less than 20
units and another 3 patients (3.2%) received more than 20 unit platelets.
CONCLUSION: The study may have future implications for the selection of platelet
donors for alloimmunized recipients in HUSM.
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