Prevalence of positive dengue serology among the blood donors in Hospital Universiti Sains Malaysia

Mohamad@Manas, Nor Nazuha (2017) Prevalence of positive dengue serology among the blood donors in Hospital Universiti Sains Malaysia. Masters thesis, Universiti Sains Malaysia.

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Introduction Blood bank has important duty to provide safe blood to the patients. As many infections have emerging and re-emerging in our populations, the duty of blood bank has become tougher. For example, dengue infection has become a serious threat to our country recently. In 2014, Kelantan has become one of the main contributors to the increase number of dengue cases in Malaysia, especially in Kota Bharu. Dengue infection can be subclinical or asymptomatic. Therefore, the aim of our study was to determine the prevalence of positive dengue serology among the asymptomatic blood donors. Methodology A cross-sectional study was conducted starting from March 2015 till February 2016 in Hospital Universiti Sains Malaysia (HUSM), Kubang Kerian. Hundred and twenty-eight samples were collected from blood donors who donated blood at blood bank and mobile blood donation programs. The samples were tested for dengue NS1 antigen, IgM, and IgG using immunochromatography method (rapid test). Results From this study, there was one sample (0.8%) out of 128 samples was positive for dengue IgM antibody. However the sample was negative for dengue IgG antibody and NS1 antigen.For dengue IgG antibody and NS1 antigen, all of 128 samples (100%) were negative. There were no significant association between gender, age, race and type of donors with positive dengue IgM antibody. Conclusion This study showed that dengue serology can be positive in asymptomatic donor. Although it still cannot be confirmed if any dengue transmission by blood transfusion in Malaysia, but these results suggest that dengue can be a possible threat to the blood supply. However, large scale study, supported by confirmatory test like viral isolation test, nucleic acid testing or molecular test should be conducted to determine the risk of transfusion- related dengue infection.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Dengue, Transmission
Subjects: R Medicine
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 08 Sep 2019 08:04
Last Modified: 22 Oct 2020 03:03

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