Mohamad@Manas, Nor Nazuha
(2017)
Prevalence of positive dengue serology among the blood donors in Hospital Universiti Sains Malaysia.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction
Blood bank has important duty to provide safe blood to the patients. As many infections
have emerging and re-emerging in our populations, the duty of blood bank has become
tougher. For example, dengue infection has become a serious threat to our country recently.
In 2014, Kelantan has become one of the main contributors to the increase number of dengue
cases in Malaysia, especially in Kota Bharu. Dengue infection can be subclinical or
asymptomatic. Therefore, the aim of our study was to determine the prevalence of positive
dengue serology among the asymptomatic blood donors.
Methodology
A cross-sectional study was conducted starting from March 2015 till February 2016 in
Hospital Universiti Sains Malaysia (HUSM), Kubang Kerian. Hundred and twenty-eight
samples were collected from blood donors who donated blood at blood bank and mobile
blood donation programs. The samples were tested for dengue NS1 antigen, IgM, and IgG
using immunochromatography method (rapid test).
Results
From this study, there was one sample (0.8%) out of 128 samples was positive for dengue
IgM antibody. However the sample was negative for dengue IgG antibody and NS1 antigen.For dengue IgG antibody and NS1 antigen, all of 128 samples (100%) were negative. There
were no significant association between gender, age, race and type of donors with positive
dengue IgM antibody.
Conclusion
This study showed that dengue serology can be positive in asymptomatic donor. Although it
still cannot be confirmed if any dengue transmission by blood transfusion in Malaysia, but
these results suggest that dengue can be a possible threat to the blood supply. However,
large scale study, supported by confirmatory test like viral isolation test, nucleic acid testing
or molecular test should be conducted to determine the risk of transfusion- related dengue
infection.
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