Azman, Khairunnuur Fairuz and Zakaria, Rahimah and Othman, Zahiruddin and Aziz, Che Badariah Abdul (2018) Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress. Journal of Taibah University for Science, 12 (3). pp. 1-12. ISSN 1658-3655
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Abstract
The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property.
| Item Type: | Article |
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article Zoom Profil Pakar (Expert Profile) > Zahiruddin Othman (Medical Sciences) |
| Depositing User: | Administrator Automasi |
| Date Deposited: | 06 Sep 2019 08:56 |
| Last Modified: | 06 Sep 2019 09:02 |
| URI: | http://eprints.usm.my/id/eprint/45338 |
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