Sahak, Nursahjohana Md
(2013)
Development Of A Nomogram To Guide
The Monitoring Of Once Daily Dosing
Gentamicin Regimen
In Hospital Melaka.
Masters thesis, Universiti Sains Malaysia.
Abstract
The exact starting dose used in once daily dosing gentamicin (ODD) has not been
clearly defined but it is typically equivalent to the sum of doses traditionally used with
conventional dosing over a 24-hour period. However, most literatures have
recommended a dosing range of 5 to 7 mg/kg/day. Despite these recommendations,
anecdotal reports have shown that the usual dose used in ODD in Malaysia was much
lower, with an average of 3.5 mg/kg. Therefore, clinical and bacteriological cures
maybe different. Consequently, published monitoring method of ODD gentamicin in the
literature may not be applicable in local setting.
This study was carried out to evaluate the practice of ODD gentamicin, to
determine its pharmacokinetic parameters and to develop a simple monitoring method
applicable in Hospital Melaka.
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