Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein

Teow, Sin Yeang (2015) Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein. PhD thesis, Universiti Sains Malaysia.

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The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells. However, the peptides are less stable in the blood, thus resulting in rapid clearance from the system and they can exhibit off-target activities. Monoclonal antibodies (MAbs) on the other hand, are stable and highly specific molecule,

Item Type: Thesis (PhD)
Subjects: R Medicine > R Medicine (General) > R735-854 Medical education. Medical schools. Research
Divisions: Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis
Depositing User: ASM Ab Shukor Mustapa
Date Deposited: 26 Jul 2019 01:21
Last Modified: 26 Jul 2019 01:21
URI: http://eprints.usm.my/id/eprint/45074

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