Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid

Gonawan, Fadzil Noor (2012) Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid. Masters thesis, Universiti Sains Malaysia.

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The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen acid. Moreover, the hydrolysis process shows an optimum performance at only 2% (v/v) dimethyl sulfoxide (DMSO) and at the reaction temperature of 30°C. The addition of 2% (v/v) DMSO has increased the conversion of substrate and further increase in the concentration of DMSO has resulted in a low initial reaction rate and conversion of substrate, however gives a high enantiomeric excess of the product (eeP).

Item Type: Thesis (Masters)
Subjects: T Technology > TP Chemical Technology > TP1-1185 Chemical technology
Divisions: Kampus Kejuruteraan (Engineering Campus) > Pusat Pengajian Kejuruteraan Kimia (School of Chemical Engineering) > Thesis
Depositing User: ASM Ab Shukor Mustapa
Date Deposited: 02 Jul 2019 01:19
Last Modified: 02 Jul 2019 01:19

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