Ultrasound features in the diagnosis of biliary atresia

Khim, Sim See (2017) Ultrasound features in the diagnosis of biliary atresia. Masters thesis, Universiti Sains Malaysia.

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Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia (non-BA) based on the surgical findings and clinical follow up. The following features were recorded: tri-angular cord sign, gall bladder morphology, liver size, and echotexture, splenic size, hepatic artery size, hepatic artery to portal vein ratio, presence of a common bile duct, and presence of subcapsular flow on colour Doppler. Sensitivity, specificity, positive and negative predictive values were calculated for each US variable. BA and non-BA groups were compared by using the Fisher exact test for categorical variables and an unpaired t test for continues variable. Results: A total of 82 infants were included in the study; 42 had surgically confirmed BA and 40 had other documented causes of neonatal jaundice. Nine US features showed a significant different between BA and non-BA group. Ultrasound able to correctly classified 82 infants into BA and non-BA group with 98% accuracy. Conclusions: BA can be diagnosed with US from other cause of conjugated hyperbilirubinemia in 98% of patients if multiple US features are carefully evaluated. These ultrasound variables may serve as independent predictors of BA.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Ultrasonography
Subjects: R Medicine > R Medicine (General)
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 17 Jun 2019 03:56
Last Modified: 22 Oct 2020 03:03
URI: http://eprints.usm.my/id/eprint/44632

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